This paper reports a critical analysis of the assessment of contaminant removal efficiency. Measurements have been carried out in a ventilated room equipped with a pine wood floor, which emits Volatile Organic Compounds (VOCs), considered as air pollutants in this paper. Thereafter, Computational Fluid Dynamics (CFD) simulations are performed. CFD results are compared to measurements to check their accuracy. Moreover, air quality within the ventilated room is numerically analysed via indices.