Multiple-skin facades were studied by means of experiments and numerical simulations. Experimental work was done on naturally and mechanically ventilated single storey multiple skin facades. Field experiments showed that good design and excellent workmanship are of crucial importance to obtain the desired performance. The measurements enables an insight into the complex nature of the airflow in naturally ventilated cavities. Measurements on a controlled experimental set-up provided data to develop and validate a numerical model. This model was then implemented in an energy simulation tool.