A six channel, computer controlled, tracer gas detection system for the measurement of infiltration rates and air movement in large single-cell industrial buildings has been designed, constructed and calibrated. This has been used for over 50 sets of tracer decay measurements in five single-cell buildings ranging in size from 4000 to 31000 m³, The buildings included a sports hall, a vehicle maintenance depot, two factory workshops and an aircraft hanger. Infiltration rates and interzonal flows were derived from the tracer decay curves using methods based on multizone theory.