This study investigates the effects of ventilation on the spread of airborne diseases. After four weeks contact with a colleague suffering from cavitary tuberculosis 27 of 67 office workers had documented tuberculin skin test conversions. Complaints by workers for more than two years previously prompted studies of the air quality in the building before and after the tuberculosis exposure. Concentrations of Carbon Dioxide in many parts of the building exceeded recommended levels, indicating inadequate ventilation with external air.