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The balance between the energy efficient thermal comfort and Indoor Air Quality (IAQ) in healthcare facilities is the main aim of this paper. The present paper will present this balance from the viewpoint of the air conditioning design. It was found that the design of the HVAC airside systems pl ays an important role for the energy consumption optimization and achieving the optimum IAQ. This paper highlights the importance of the proper airside design on the energy consumption, thermal comfort and IAQ. The present work introduces some recommendations for airside designs to facilitate the development of optimum HVAC systems.