In order to address the lack of reliable methods that can analyze the overall effects of PDEC tower with a spray system, analytical models that predict supply air conditions of the system were implemented into a whole building energy simulation program EnergyPlus. This paper describes the simulation algorithm of the new module to predict the performance of the system. Case studies were performed to verify the capability of the module. The results of the case studies showed that the module adequately predicted the supply air conditions, and it was also capable of estimating energy performance and indoor thermal environment when the system served as a primary cooling system.