In this study the spatio-dynamic temperature response in a ventilated room to variations of the supply air temperature was modelled for a wide range of ventilation rates. The model structure was first formulated by applying standard heat transfer theory to zones of better mixing. Spatio-temporal temperature data were then exploited in statistical terms to estimate the physically meaningful model parameters. The dynamic model yielded an excellent fit to the experimental data and was found to characterise the spatially heterogeneous nature of the air flow pattern quite well.