This paper deals specifically with analysis of the thermal, airflow and daylighting performance of the façade elements and in particular with the Double Skin Façade (DSF) applied to the south and southeast facing office spine of a laboratory building. DSF have been applied successfully in Europe for a number of years with the desire to create a more natural internal climate, good daylight quality and access to outdoor air. The focus of this new study is not just on energy reduction and a design of a better work environment but also show building performance simulations support the design process directly.