For this paper 40 studies based on the role of ventilation in airborne transmission of infectious agents in the built environment have been reviewed with two specific research questions :- Is there enough evidence to support that the ventilation and airflow pattern are the causes that contribute for the spread of airborne infectious diseases ?- If so , is there good evidence or data to support the specification and quantification of minimum ventilation requirements to minimize the transmission of airborne infectious deseases ?It appears a strong need for a multidisciplinary study that would investigate disease outbreaks, and the impact of indoor air environments on the spread of airborne infectious diseases.