This paper presents a simulation-based study of a decentralized, „low-exergy‟ (or LowEx) space cooling system for a commercial office currently under construction in Singapore. We used asdesigned building and system characteristics to parametrize a TRNSYS simulation model of the energy supply system. We also compared the performance of the LowEx air-conditioning system against a conventional air handling unit. Our study indicates that the LowEx concept can reduce electricity consumption for space cooling by up to 40% when complemented by a low-lift chiller and as high as 20% when driven by standard chillers.